Core Innovative Antibody Platform
Independently build four core platform technologies with global competitiveness
Our Four Proprietary Antibody Platforms
At CentryMed, we are pioneering next-generation T-Cell Engagers through a world-class antibody discovery and development engine. Our four fully proprietary technology platforms are purpose-built to create highly selective, multifunctional TCEs that address significant unmet medical needs.
Multichannel Antibody Discovery Platform
H-BiTE: T-cell Engaging (TCE) Bispecific Antibody Platform
Pro-BiTE: Protease-Activated T-cell Engaging Antibody Platform
Multifunctional T-cell Engager Platform
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Multichannel Antibody Discovery PlatformHarnessing ultra-large fully human IgM antibody libraries
4 ultra-large human IgM libraries: Fab and dAb formats with industry-leading diversity and rapid screening cycles (1–2 weeks). dAb capabilities are extremely rare globally.Advantages:High epitope diversity and affinity flexibilityFully human antibodies—no humanization neededRapid candidate generationAnimal immune libraries: Proprietary hybridoma + phage display platforms for mouse, rabbit, and monkey. Enable broader epitope coverage and higher-quality antibodies. -
H-BiTE: T-cell Engaging (TCE) Bispecific Antibody PlatformEnhanced Potency, Safety, and Manufacturability
Designed to overcome poor druggability and safety challenges of traditional bispecificsKey features:Extended therapeutic window with favorable safety profileMonoclonal-like manufacturability—simple, stable, no aggregation or degradationOptimized pharmacokinetics and dual-target binding efficiency -
Pro-BiTE: Protease-Activated T-cell Engaging Antibody PlatformNext-Generation Safety Switch for Targeted Immune Activation
Global first-in-class design, relying on tumor-specific protease activationMechanism:Inactive in normal tissue and bloodActivated only in tumor microenvironmentOver 10,000-fold sealing efficiency; >100x wider therapeutic windowDemonstrated excellent tolerability in non-human primates, with 100-fold safety improvement -
Multifunctional T-cell Engager PlatformMultifunctional Precision for Complex Disease Mechanisms
Flexible structural formats suited to diverse target combinationsKey benefits:Simultaneous mechanisms of action for greater efficacyBroad applicability to hard-to-target cancersMitigates resistance and relapse from single-target therapiesTunable design enables balance between potency and safety